| Toll样受体抗体抑制脂多糖激活巨噬细胞的吞噬活性 |
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| 引用本文： | 王梁华,冯煜,钟山,朱玉平,娄永华,焦炳华.Toll样受体抗体抑制脂多糖激活巨噬细胞的吞噬活性[J].生物化学与生物物理进展,2001,28(3):367-371. |
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| 作者姓名： | 王梁华 冯煜 钟山 朱玉平 娄永华 焦炳华 |
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| 作者单位： | 第二军医大学基础医学部卫生毒理学教研室, 上海 200433;第二军医大学基础医学部卫生毒理学教研室, 上海 200433;第二军医大学基础医学部卫生毒理学教研室, 上海 200433;第二军医大学基础医学部卫生毒理学教研室, 上海 200433;第二军医大学基础医学部卫生毒理学教研室, 上海 200433;第二军医大学基础医学部卫生毒理学教研室, 上海 200433 |
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| 基金项目： | 国家自然科学基金资助项目(39970041). |
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| 摘 要： | 应用脂多糖(LPS)激活巨噬细胞后其吞噬能力大大增强, 以此为模型发现TLR2的多抗能部分抑制LPS激活巨噬细胞吞噬金葡萄球菌的能力, 也能部分阻断对U937细胞的吞噬活性. TRAIL或TNFα多克隆抗体同样能起到类似作用. 实验还发现低浓度血清培养亦在一定程度上抑制LPS激活巨噬细胞的吞噬作用. 结果证实TLR2能介导LPS的功能, 而某些血清因子参与了介导LPS的信号转导过程, 提示LPS激活巨噬细胞吞噬能力的提高与诱导表达TRAIL等细胞因子有关.
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| 关 键 词： | 脂多糖 TLR2 抗体 巨噬细胞 TRAIL，TNFα |
| 收稿时间： | 2000/6/12 0:00:00 |
| 修稿时间： | 2000/8/23 0:00:00 |
The Inhibition on Phagocytosis of Lipopolysaccharide-stimulated Macrophages by Polyclone Antibody of TLR2 |
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| WANG Liang-Hu,FENG Yu,ZHONG Shan,ZHU Yu-Ping,LOU Yong-Hua and JIAO Bing-Hua.The Inhibition on Phagocytosis of Lipopolysaccharide-stimulated Macrophages by Polyclone Antibody of TLR2[J].Progress In Biochemistry and Biophysics,2001,28(3):367-371. |
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| Authors: | WANG Liang-Hu FENG Yu ZHONG Shan ZHU Yu-Ping LOU Yong-Hua and JIAO Bing-Hua |
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| Institution: | Department of Health Toxicology, College of Basic Medicine, Second Military of Medical University, Shanghai 200433, China;Department of Health Toxicology, College of Basic Medicine, Second Military of Medical University, Shanghai 200433, China;Department of Health Toxicology, College of Basic Medicine, Second Military of Medical University, Shanghai 200433, China;Department of Health Toxicology, College of Basic Medicine, Second Military of Medical University, Shanghai 200433, China;Department of Health Toxicology, College of Basic Medicine, Second Military of Medical University, Shanghai 200433, China;Department of Health Toxicology, College of Basic Medicine, Second Military of Medical University, Shanghai 200433, China |
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