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Production of a monoclonal antibody by ascites, hollow fiber system, and transgenic plants for vaccine production using CB.Hep-1 mAb as a study case |
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| Authors: | Rodolfo Valdés Andrés Tamayo Marcos González Sigifredo Padilla Déborah Geada William Ferro Lorely Milá Leonardo Gómez Rosario Alemán Alberto Leyva Cristina García Otto Mendoza Tatiana Alvarez Lamay Dorta Yanet Villega Dobián Cecilia Hasel Aragón Tatiana González Maylín La O Jorge López |
| Affiliation: | 1. Monoclonal Antibody Production Department, Center for Genetic Engineering and Biotechnology, Havana, 10600, Cuba 2. Institute of Tobacco Research, Havana, 3500, Cuba 3. Quality Assurance Direction, Center for Genetic Engineering and Biotechnology, Havana, 10600, Cuba 4. Process Control Derpatment, Center for Genetic Engineering and Biotechnology, Havana, 10600, Cuba 5. Quality Control Direction, Center for Genetic Engineering and Biotechnology, Havana, 10600, Cuba |
| Abstract: | Monoclonal antibody (mAb) production methods (ascites, in vitro technologies, transgenic animals, and dicot or monocot transgenic plants; moss, algae) have been improved since they were first developed in 1975. In this study, we illustrate a summary of a study case in which mice, a hollow fiber system, and tobacco transgenic plants were assessed for the production of mAb for vaccine manufacturing and vaccine production. |
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