Parental transmission of <Emphasis Type="Italic">HLA-DRB1*15 </Emphasis>in multiple sclerosis |
| |
| Authors: | Sreeram V Ramagopalan Blanca M Herrera Jordana T Bell David A Dyment Gabriele C DeLuca Matthew R Lincoln Sarah M Orton Michael J Chao A Dessa Sadovnick George C Ebers |
| |
| Institution: | (1) Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK;(2) Department of Clinical Neurology, University of Oxford, Oxford, UK;(3) Department of Medical Genetics and Faculty of Medicine, Division of Neurology, University of British Columbia, Vancouver, Canada;(4) University Department of Clinical Neurology, Level 3, West Wing, John Radcliffe Hospital, Oxford, OX3 9DU, UK |
| |
| Abstract: | Chen et al. found that the CA haplotype of protein C -1654C/T and -1641G/A was associated with increased risk of death and
organ dysfunction in Chinese Han patients with severe sepsis (Hum Genet 123:281–287, 2008). We similarly tested for association
of the C allele of protein C 673 T/C (rs2069912) (linkage disequilibrium with the CA haplotype, D′ = 100%) in a cohort of 100 North American East Asians with severe sepsis. The C allele was associated with increased mortality
and organ dysfunction, consistent with Chen et al.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users.
Support: Sirius Genomics Inc., Canadian Institutes of Health Research. Keith R. Walley is a Michael Smith Foundation for Health
Research Distinguished Scholar. |
| |
| Keywords: | |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
