A study of the effects of buspirone, BMY 13805, and 1-PP on dopaminergic metabolism in the nucleus accumbens using in vivo voltammetry in freely moving rats |
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| Authors: | A Louilot M Le Moal H Simon |
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| Institution: | 1. Key Laboratory of Pesticides & Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China;2. School of Mathematics and Statistics, Wuhan University, Wuhan 430072, China;3. Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis, College of Chemistry, Central China Normal University, Wuhan 430079, China;1. Institute for Clean Energy and Advanced Materials, Faculty of Materials and Energy, Southwest University, Chongqing 400715, PR China;2. Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies, Southwest University, Chongqing 400715, PR China;3. Department of Chemical & Biomolecular Engineering, National University of Singapore, Kent Ridge, Singapore 117576, Singapore;1. Department of Neurology, Shanghai Changhai Hospital, The Second Military Medical University, Shanghai, PR China;2. Department of Neurology, General Hospital of Central Theater Command of Chinese People''s Liberation Army, Wuhan, PR China;3. Student Team of Clinical Medicine, The Second Military Medical University, Shanghai, PR China;4. Department of Psychiatry, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada;1. Department of Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam, Netherlands;1. Department of Immunology and Cell Biology, CRCHUS, Sherbrooke, QC, Canada;2. Division of Endocrinology, Department of Medicine, Université de Sherbrooke, CRCHUS, Sherbrooke, QC, Canada;1. The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Zhengzhou University, Zhengzhou 450001, People''s Republic of China;2. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Collaborative Innovation Center of Tropical Biological Resources, Hainan Normal University, Hainan Haikou 571158, People''s Republic of China;3. College of Sciences, Henan Agricultural University, Zhengzhou 450002, People''s Republic of China;4. Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan |
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| Abstract: | The effects of buspirone, a buspirone analogue (BMY 13805) and a buspirone metabolite (1-PP) on dopaminergic metabolism in the nucleus accumbens were investigated using in vivo voltammetry. Differential pulse voltammetry coupled with electrochemically pretreated carbon fiber electrodes was used to provide a continuous and selective measure of the 3,4-dihydroxyphenylacetic acid (DOPAC). An implanted micromanipulator enabled the use of freely moving animals. Buspirone injections induced a marked and rapid increase of the DOPAC peak in the nucleus accumbens. Buspirone was 10 times more potent when injected subcutaneously than intraperitoneally. BMY 13805 and 1-PP were without effect on dopaminergic metabolism in the nucleus accumbens. In conclusion, the anxiolytic properties of these drugs and their effects on dopaminergic metabolism do not appear related. |
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