Site-related differences in the localization of the monoclonal antibody OX7 in SL2 and SL1 lymphomas |
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Authors: | Howard Sands Peter L. Jones William P. Neacy Sudhir A. Shah Brian M. Gallagher |
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Affiliation: | (1) Biomedical Products Department, Immunopharmaceutical Research and Development Department, E. I. duPont de Nemours and Co. (Inc.), 331 Treble Cove Road, 01862 North Billerica, Massachusetts, USA |
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Abstract: | Summary The uptake of a monoclonal antibody (OX7) by murine lymphomas (SL1, SL2) growing in two sites in the mouse were compared. SL2 tumors grown in the subrenal site showed greater specific antibody uptake than did the same tumor grown in the subcutaneous site. Major differences in membrane bound antibody, in vitro antibody binding patterns, and gamma scintillation camera imaging were also observed between the two sites. These differences may be due to the greater blood flow measured in tumors growing in the subrenal capsule than those growing at the subcutaneous site. The differences observed in antibody uptake of the same tumor growing in two different sites raises questions concerning the choice of animal model systems that can be used to predict clinical utility. |
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