Failure to convert Bordetella parapertussis to Bordetella pertussis with a pertussis phage |
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Authors: | Marja Paloheimo,Rose-Marie Ö lander,Kate Runeberg-Nyman |
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Affiliation: | Research Laboratories of the Finnish State Alcohol Company, Alko Ltd, Helsinki, Finland;Department of Bacteriology, National Public Health Institute, Helsinki, Finland |
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Abstract: | To analyze the described lysogenic conversion of Bordetella parapertussis to a Bordetella pertussis-like form we used the phage 134 to lysogenize a B. parapertussis strain. Southern blot analysis of the isolated ‘lysogens’ showed that they were not true lysogens, but rather chronically infected strains. These pseudo-lysogens did not show any changes in virulence properties compared with the parental strain. The only difference we could show was a change in the LPS-structure: the pseudolysogens had a rough LPS, like B. pertussis, whereas the parental B. parapertussis strain was smooth. |
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Keywords: | Bordetella pertussis Bordetella parapertussis Lysogenic conversion Bacteriophage |
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