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Novel 3,4-dihydroquinolin-2(1H)-one inhibitors of human glycogen phosphorylase a |
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| Authors: | Rosauer Keith G Ogawa Anthony K Willoughby Chris A Ellsworth Kenneth P Geissler Wayne M Myers Robert W Deng Qiaolin Chapman Kevin T Harris Georgianna Moller David E |
| Institution: | a Department of Basic Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA b Department of Metabolic Disorders-Diabetes, Merck Research Laboratories, Rahway, NJ 07065, USA c Department of Molecular Systems, Merck Research Laboratories, Rahway, NJ 07065, USA |
| Abstract: | The preparation of a series of substituted indoles coupled to six- and seven-membered cyclic lactams is described and their role as human glycogen phosphorylase a inhibitors discussed. The SAR of the indole moiety and lactam ring are presented. |
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