5-HETE congeners as modulators of cell proliferation |
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| Authors: | Miller T A Ghosh J Myers C E Macdonald T L |
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| Affiliation: | Departnent of Chemistry, University of Virginia, Charlottesville 22901, USA. |
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| Abstract: | The synthesis and assessment of the mitogenic properties of 5-HETE congeners are reported. These studies represent an effort to develop a structure-activity profile for ligands of the 5-HETE/5-oxoETE G-protein coupled receptor(s). Many of these agents possess mitogenic activity that equals or exceeds that of racemic 5-HETE family constituents in prostate cancer cell lines. |
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