Inheritance of Ag-stainability of nucleolus organizer regions |
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| Authors: | Mikelsaar A -V Schwarzacher H G Schnedl W Wagenbichler P |
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| Institution: | (1) Histologisch-Embryologisches Institut der Universität Wien, Schwarzspanierstraße 17, A-1090 Wien, Austria;(2) I. Frauenklinik der Universität Wien, Spitalgasse 13, A-1090 Wien, Austria;(3) Present address: Central Medical Research Laboratory, Tartu State University, USSR |
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| Abstract: | Summary The Ag-stainability of the nucleolus organizer region (NOR) was studied in the acrocentric chromosomes identified by Q-banding in cultured lymphocytes from seven children with trisomy 21 and their parents. The observed Ag-NOR patterns were in accordance with chromosomal inheritance except for a slight intraindividual variation which might be explained mainly by technical causes. In two cases the meiotic nondisjunction could be attributed to one of the parents, once to the father, and once to the mother. It is concluded that the Ag-stainability of the NORs is in general a heritable characteristic of the acrocentric chromosomes in maximally activated cells as, e.g., cultured lymphocytes. It may reflect individual differences in the amount of rDNA as well as differences in the capacity for NOR activation. |
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