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Gene expression profiles of mouse spermatogenesis during recovery from irradiation |
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| Authors: | Fozia J Shah Masami Tanaka John E Nielsen Teruaki Iwamoto Shinichi Kobayashi Niels E Skakkebæk Henrik Leffers Kristian Almstrup |
| Institution: | (1) Department of Growth and Reproduction GR-5064, University of Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen O, Denmark;(2) Institute for Animal Experimentation, St. Marianna University Graduate School of Medicine, 2-16-1 sugao, 216-8511 Miyamae-ku, Kawasaki, Japan;(3) Department of Pharmacology, St. Marianna University Graduate School of Medicine, 2-16-1 sugao, 216-8511 Miyamae-ku, Kawasaki, Japan;(4) Center for infertility and IVF, International University of Health and Welfare Hospital, 537-3 Iguchi, 329-2763 Nasushiobara, Japan |
| Abstract: | BackgroundIrradiation or chemotherapy that suspend normal spermatogenesis is commonly used to treat various cancers. Fortunately, spermatogenesis in many cases can be restored after such treatments but knowledge is limited about the re-initiation process. Earlier studies have described the cellular changes that happen during recovery from irradiation by means of histology. We have earlier generated gene expression profiles during induction of spermatogenesis in mouse postnatal developing testes and found a correlation between profiles and the expressing cell types. The aim of the present work was to utilize the link between expression profile and cell types to follow the cellular changes that occur during post-irradiation recovery of spermatogenesis in order to describe recovery by means of gene expression. |
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