Chromosomal regions harboring genes for the work to femur failure in mice |
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| Authors: | Xinmin Li Godfred Masinde Weikuan Gu Jon Wergedal Melanie Hamilton-Ulland Shizhong Xu Subburaman Mohan David J Baylink |
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| Institution: | (1) Molecular Genetics Division, Musculoskeletal Disease Center, JL Pettis VA Medical Center and Loma Linda University, 11201 Benton Street (151), Loma Linda, CA 92357, USA,;(2) Department of Botany and Plant Sciences, University of California, Riverside, CA 92521–0124, USA, |
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| Abstract: | The work to failure is defined as the maximum energy bone can absorb before breaking, and therefore is a direct test of the
risk of fracture. To determine the genetic loci influencing work to failure, we have performed a high density genome-wide
scan in 633 (MRL × SJL) F2 female mice. Five loci (P <0.005) with significant effects on work to failure were found on chromosomes 2, 7, 8, 9, and X, which collectively explained
around 20% variance of work to femur failure in F2 mice. Of those, only the QTL on chromosome 9 was concordant with bone mineral density (BMD) QTLs. Eight significant interactions
(P <0.01) between marker loci were identified, which accounted for an equivalent amount of F2 variance (23%) to combined single QTL effects. Our results demonstrate that most of the genetic loci regulating work to failure
are different from those for BMD in the 7-week-old female mice. If this is also true in humans, this finding will challenge
the predictive value of BMD for the risk of fracture.
Electronic Publication |
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| Keywords: | Work to failure Bone mineral density Quantitative trait loci Instron |
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