Effect of mouse genotype on interferon production. I. Lines congenic at theIf-1 locus |
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Authors: | E. De Maeyer J. De Maeyer-Guignard Donald W. Bailey |
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Affiliation: | (1) Institut du Radium-Universite de Paris-Sud, 91405 Orsay, France;(2) The Jackson Laboratory, 04609 Bar Harbor, Maine |
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Abstract: | The level of circulating Interferon induced in mice by Newcastle disease virus is controlled by a single codominant locus,If-1, with two alleles,If-1l for low andIf-1h for high production. This locus is linked to the histocompatibility locusH-28. Of three C57BL/6By lines congenic for the BALB/cBy allele atH-28, two are carrying the BALB/cBy allele and one, the C57BL/6By allele atIf-1. Thus, mouse strains that are genetically very similar but different in their production of NDV-induced circulating Interferon now are available.A preliminary report of these studies was presented at the ASM meeting at Miami Beach in May 1973. |
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