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Elevated expression of vascular endothelial growth factor (VEGF) 120 in parthenogenetic porcine placentas |
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| Authors: | Yang Han Hongsheng Ouyang Dongsheng Che Xianju Chen Yongye Huang I. A. Elfaki elhag Daxin Pang Zhanjun Li |
| Affiliation: | 1. Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Science, Jilin University, 5333#, Xi’an Road, Changchun, 130062, China 2. Key Laboratory of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, Changchun, 130118, China 3. Zoology Department, Faculty of Science, Kordofan University, P.O. Box 160, El obied 517, North Kordofan, Sudan |
| Abstract: | Most mammalian parthenogenetic embryos are unable to develop to term due to placental defects, potentially caused by decreased vasculogenesis and angiogenesis of the parthenogenetic placenta. Here we have compared the expression status of vascular endothelial growth factor (VEGF) and angiopoietin family members between normally developing and parthenogenetic porcine placentas. The result showed significantly reduced expression of these genes but elevated expression of VEGF 120 in the parthenogenetic porcine placenta (p < 0.05). We postulate that the abnormal expression levels of VEGF and angiopoietin family members and, especially, the elevated expression of VEGF 120 observed in parthenogenetic porcine placentas are related to the early miscarriage of parthenogenetic embryos in pigs. |
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