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The subtype CD200-positive,chorionic mesenchymal stem cells from the placenta promote regeneration of human hepatocytes |
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| Authors: | Jian Wang Zhengyan Zhu Yong Huang Peng Wang Ying Luo Yingtang Gao Zhi Du |
| Affiliation: | 1. Department of Hepatobiliary Surgery, The Third Central Clinical College of Tianjin Medical University, Tianjin, China 2. Key Laboratory of Artificial Cell, Institute of Hepatobiliary Disease, The Third Central Hospital of Tianjin, Tianjin, China 3. Department of Hepatobiliary Surgery, The Third Central Houspital of Tianjin, Tianjin, 300170, China |
| Abstract: | Human placental mesenchymal stem cells (hPMSCs), for the treatment of fulminant hepatic failure, have been widely studied. Only a few studies have investigated the effect of the subtype CD200+hPMSCs on regeneration of human hepatocytes. CD200+hPMSCs can down-regulate activity of several immunocytes and suppress TNF-α secretion from macrophages via the CD200-CD200R axis. We have investigated the influence of CD200-positive human placenta chorionic mesenchymal stem cells (CD200+hPCMSCs) on metabolism, proliferation and apoptosis of human hepatocytes in vitro. CD200+hPCMSCs promote urea synthesis, albumin secretion and hepatocytes proliferation at co-culture ratios of 1:1 and 3:1. Additionally, CD200+hPCMSCs inhibit hepatocyte apoptosis via up-regulation of an anti-apoptotic protein, Bcl-xL. Thus, CD200+hPCMSCs can provide supportive benefit for the regeneration of human hepatocytes and also have immunosuppressive properties. Therefore, CD200+hPCMSCs may be an ideal candidate for stem cell-based therapy in hepatic failure. |
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