Development of motorized plasma lithography for cell patterning |
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Authors: | Shinji Deguchi Yohei Nagasawa Akira C Saito Tsubasa S Matsui Sho Yokoyama Masaaki Sato |
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Institution: | 1. Department of Bioengineering and Robotics, Tohoku University, Sendai, Japan 2. Department of Nanopharmaceutical Sciences, Nagoya Institute of Technology, Gokiso, Showa, Nagoya, 466-8555, Japan 3. Department of Biomedical Engineering, Tohoku University, Sendai, Japan 4. Department of Biomolecular Sciences, Tohoku University, Sendai, Japan 5. Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Japan
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Abstract: | The micropatterning of cells, which restricts the adhesive regions on the substrate and thus controls cell geometry, is used to study mechanobiology-related cell functions. Plasma lithography is a means of providing such patterns and uses a spatially-selective plasma treatment. Conventional plasma lithography employs a positionally-fixed mask with which the geometry of the patterns is determined and thus is not suited for producing on-demand geometries of patterns. To overcome this, we have manufactured a new device with a motorized mask mounted in a vacuum chamber of a plasma generator, which we designate motorized plasma lithography. Our pilot tests indicate that various pattern geometries can be obtained with the control of a shielding mask during plasma treatment. Our approach can thus omit the laborious process of preparing photolithographically microfabricated masks required for the conventional plasma lithography. |
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