Light-Dependent Compartmentalization of Transducin in Rod Photoreceptors |
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Authors: | Nikolai O. Artemyev |
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Affiliation: | Department of Molecular Physiology and Biophysics, University of Iowa College of Medicine, 5-532 Bowen Science Building, 51 Newton Road, Iowa, IA 52242, USA. nikolai-artemyev@uiowa.edu |
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Abstract: | Three major visual signaling proteins, transducin, arrestin, and recoverin undergo bidirectional translocations between the outer segment and inner compartments of rod photoreceptors in a light-dependent manner. The light-dependent translocation of proteins is believed to contribute to adaptation and neuroprotection of photoreceptor cells. The potential physiological significance and mechanisms of light-controlled protein translocations are at the center of current discussion. In this paper, I outline the latest advances in understanding the mechanisms of bidirectional translocation of transducin and determinants of its steady-state distribution in dark- and light-adapted photoreceptor cells. |
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Keywords: | Retina Photoreceptor Transducin Arrestin Light adaptation Phototransduction |
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