Plasmodium berghei berghei: Irradiated sporozoites of the ANKA strain as Immunizing Antigens in mice |
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| Authors: | Richard L. Beaudoin Cloyce P.A. Strome Theodore A. Tubergen Fred Mitchell |
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| Affiliation: | Division of Immunoparasitology, Department of Clinical and Experimental Immunology, Naval Medical Research Institute, Bethesda, Maryland 20014, U.S.A. |
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| Abstract: | Mice were protected against challenge with infective Sporozoites following immunization with X-ray irradiated Sporozoites. The immunity lasted at least 8 weeks. Mice immune against sporozoite challenge remained fully susceptible to challenge with erythrocytic stages. Immunization of mice with extracts of mosquito thorax failed to protect them, indicating that mosquito antigens were not directly responsible for the immunity observed in the basic experiments. |
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| Keywords: | Sporozoite Parasitic protozoa ANKA strain Immunizaion Malaria Mice Vaccine X-ray Mosquito vector Antigen |
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