mRNA Localization: An Orchestration of Assembly,Traffic and Synthesis |
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Authors: | Lei Xing Gary J. Bassell |
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Affiliation: | 1. Department of Cell Biology, Emory University School of Medicine, , Atlanta, GA, 30322 USA;2. Department of Neurology, Emory University School of Medicine, , Atlanta, GA, 30322 USA |
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Abstract: | Asymmetrical mRNA localization and subsequent local translation provide efficient mechanisms for protein sorting in polarized cells. Defects in mRNA localization have been linked to developmental abnormalities and neurological diseases. Thus, it is critical to understand the machineries mediating and mechanisms underlying the asymmetrical distribution of mRNA and its regulation. The goal of this review is to summarize recent advances in the understanding of mRNA transport and localization, including the assembly and sorting of transport messenger ribonucleic protein (mRNP) granules, molecular mechanisms of active mRNP transport, cytoskeletal interactions and regulation of these events by extracellular signals. |
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Keywords: | cytoskeleton dynein kinesin molecular motor mRNA localization mRNA transport myosin RNA‐binding protein RNA granule |
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