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Ascaris suum and Toxocara canis: Egg extract antigens in guinea pigs and the macrophage migration inhibition test |
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| Authors: | HSW Wong JA Embil RL Ozere |
| Institution: | Departments of Microbiology and Pediatrics, Dalhousie University, and the Infectious Disease Research Unit, the Izaak Walton Killam Hospital for Children, Halifax, Nova Scotia, B3J 3G6, Canada |
| Abstract: | Guinea pigs immunized with 500 μg of either Ascaris suum or Toxocara canis egg extracts, emulsified with Freund's complete adjuvant, were skin tested with both the homologous and heterologous antigens. Cross-reactions were observed in both groups. Migration of macrophages from sensitized animals was more inhibited by homologous than by heterologous antigens. Lymph-node lymphocytes from sensitized animals were stimulated to incorporate 8H]thymidine similarly by both antigens. |
| Keywords: | Guinea pigs Parasite egg extracts Parasitic nematodes Cellular immunity Homologous and heterologous antigens Skin test macrophage migration inhibition test Lymphocyte transformation Cross-immunity |
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