Effect of procaine on development of ‘ridges’ and ‘domes’ in primary cell cultures from mammary glands of untreated virgin mice: The role of cell density in the occurrence of ‘domes’ |
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Authors: | GJ Wiepjes AS Visser FJA Prop |
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Institution: | Division for Experimental Cytopathology, Pathologish Anatomisch Laboratorium, Academisch Ziekenhuis “Wilhelmina Gasthuis”, Amsterdam, The Netherlands |
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Abstract: | Primary cell cultures from mammary glands of virgin mice that were not pretreated with hormones were subjected to: (1) procaine; (2) insulin+ prolactin +hydrocortisone; (3) a combination of (1) and (2). Procaine caused a ‘ridge’ effect similar to that of the hormones. The combination of procaine with the hormones caused a still stronger ‘ridge’ effect as well as the formation of ‘domes’. The formation of ‘domes’ is suggested to be dependent on cell density. |
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Keywords: | To whom reprint requests should be addressed |
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