Etoposide-loaded nanoparticles made from glyceride lipids: Formulation,characterization, in vitro drug release,and stability evaluation |
| |
Authors: | L Harivardhan Reddy R S R Murthy |
| |
Institution: | (1) Drug Delivery Research Laboratory, Center of Relevance and Excellence in New Drug Delivery Systems (NDDS), Pharmacy Department, G H Patel Building, Donor’s Plaza, MS University, Fatehgunj, 390002 Baroda, Gujarat, India |
| |
Abstract: | The aim of the study was to prepare etoposide-loaded nanoparticles with glyceride lipids and then characterize and evaluate
the in vitro steric stability and drug release characteristics and stability. The nanoparticles were prepared by melt emulsification
and homogenization followed by spray drying of nanodispersion. Spray drying created powder nanoparticles with excellent redispersibility
and a minimal increase in particle size (20–40 nm). Experimental variables, such as homogenization pressure, number of homogenization
cycles, and surfactant concentration, showed a profound influence on the particle size and distribution. Spray drying of Poloxamer
407-stabilized nanodispersion lead to the formation of matrix-like structures surrounding the nanoparticles, resulting in
particle growth. The in vitro steric stability test revealed that the lipid nanoparticles stabilized by sodium tauroglycocholate
exhibit excellent steric stability compared with Poloxamer 407. All 3 glyceride nanoparticle formulations exhibited sustained
release characteristics, and the release pattern followed the Higuchi equation. The spray-dried lipid nanoparticles stored
in black polypropylene containers exhibited excellent long-term stability at 25°C and room light conditions. Such stable lipid
nanoparticles with in vitro steric stability can be a beneficial delivery system for intravenous administration as long circulating
carriers for controlled and targeted drug delivery.
Published: September 30, 2005 |
| |
Keywords: | lipid nanoparticles high-pressure homogenization spray drying Poloxamer 407 steric stability |
本文献已被 PubMed SpringerLink 等数据库收录! |
|