1-[(Benzofuran-2-yl)phenylmethyl]-triazoles and -tetrazoles - potent competitive inhibitors of aromatase. |
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| Authors: | T K Vinh M Ahmadi P O Delgado S F Perez H M Walters H J Smith P J Nicholls C Simons |
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| Institution: | Welsh School of Pharmacy, Cardiff University, UK. |
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| Abstract: | The synthesis of a series of novel 1-(benzofuran-2-yl)phenylmethyl]-triazoles and -tetrazoles is described. The compounds were tested for human placental aromatase inhibition in vitro, using 1beta-3H]-androstenedione as the substrate for the aromatase enzyme, the percentage inhibition and IC50 data is included. |
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