Functional interferon system is required for clearance of lassa virus |
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| Authors: | Yun Nadezhda E Poussard Allison L Seregin Alexey V Walker Aida G Smith Jennifer K Aronson Judith F Smith Jeanon N Soong Lynn Paessler Slobodan |
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| Affiliation: | Galveston National Laboratory, Institute for Human Infectious and Immunity, Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA. neyun@utmb.edu |
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| Abstract: | Lassa virus (LASV) is the causative agent of Lassa hemorrhagic fever (LF) in humans, a deadly disease endemic to West Africa that results in 5,000 to 10,000 deaths annually. Here we present results demonstrating that functional type I and type II interferon (IFN) signaling is required for efficient control of LASV dissemination and clearance. |
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