tRNA processing in human mitochondrial disorders |
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Authors: | Judy P Masucci Eric A Schon |
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Institution: | (1) Department of Genetics and Development, Columbia University, 10032 New York, NY, USA;(2) Department of Neurology, Room 4-431, Columbia University, 630 West 168th Street, 10032 New York, NY, USA |
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Abstract: | Many human mitochondrial disorders are associated with mutations in tRNA genes or with deletions of regions containing tRNA genes, all of which may be suspected to play a role in recognition by RNase P. Here we describe the analysis of five such mutations. The results presented here demonstrate that none of thse mutations result in errors in RNase P function. Further studies of mutations in tRNAs need to be pursued to elucidate the identity elements for RNase P function in mammalian mitochondria. |
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Keywords: | mitochondria RNase P tRNA processing mtDNA |
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