Immune response genes in inbred rats. II. Segregation studies of the GT and GA genes and their linkage to the major histocompatibility locus |
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Authors: | Dieter Armerding David H Katz Baruj Benacerraf |
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Institution: | (1) The Department of Pathology, Harvard Medical School, Boston, Massachusetts |
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Abstract: | Genetic analysis of the high responder-non-(or low) responder differences between WF and ACI rats to the synthetic copolymers GT and GA established singleIr-genes for both antigens and dominance for high responder status.Ir-GT andIr-GA are linked to the major histocompatibility locus. It could be demonstrated that only T cells carrying the high responderIr-GT gene undergo in vitro blast transformation to GT. The advantages of the rat systems for further studies of the regulatory role ofIr-genes on the cellular level are discussed.Abbreviations cpm
counts per minute
- DHR
delayed hypersensitivity reaction
- GA
random synthetic copolymer of L-glutamic acid50, L-alanine50, M.W. 45,000
- GT
random synthetic copolymer of L-glutamic acid50, L-tyrosine50, M.W. 22,000
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Ir gene
immune response gene
- MLC
mixed lymphocyte cultures
- LDH
lactic dehydrogenase
- (T,G)-A-L
branched chain synthetic polymer of poly-L (tyrosine, glutamic acid)-poly-D, L-alanine-poly-L-lysine
Rat Strains ACI
ACI/MaI
- WF
Wistar Furth
- AUG
August 28807/Cr |
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Keywords: | |
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