Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 1: design of potent and specific 3,9-diazaspiro[5.5]undecanes |
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| Authors: | Smyth M S Rose J Mehrotra M M Heath J Ruhter G Schotten T Seroogy J Volkots D Pandey A Scarborough R M |
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| Institution: | COR Therapeutics, Inc, Department of Medicinal Chemistry and Biology, South San Francisco, CA 94080, USA. |
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| Abstract: | The synthesis and biological activity of novel glycoprotein IIb-IIla antagonists containing the 3,9-diazaspiro5.5]undecane nucleus are described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of the spirocyclic structures as a central template for nonpeptide RGD mimics. |
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