The ultrastructure of the neurons of a graft developing in the brain of rats experiencing hypoxia

Fragments of the brain cortex of 17- or 18-day-old rat embryos were allotransplanted into the brain cortex of rats subjected to hypoxia. Four days later the graft consisted of mixed differentiating neuroblasts. By the 100th to 130th day after transplantation the graft contained mature neurons, differentiating neurons and neuroblasts. Hypochromic neurons showing the signs of intracellular reparation were also detected. A well-developed neuropile was localized inside the graft. In contrast to the normal brain, neurons in the graft were not organized in layers.