Caenorhabditis briggsae: effects of aminopterin |
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| Authors: | M J Kisiel S Himmelhoch B M Zuckerman |
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| Affiliation: | 1. Laboratory of Experimental Biology, College of Food and Natural Resources, University of Massachusetts, East Wareham, Massachusetts 02538, USA;2. Department of Biological Ultrastructure, Weizmann Institute, Rehovot, Israel |
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| Abstract: | The characteristic features of senescence developed prematurely in Caenorhabditis briggsae treated with the DNA synthesis inhibitor aminopterin at the minimum dosage which inhibits gonad formation. In addition, aminopterin induced other changes which thus far have not been associated with normal aging of C. briggsae. Interpretations of these results are given based on current knowledge of the mode action of aminopterin and an extant theory of aging. |
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