Localisation of a dystrophin-related autosomal gene to 6q24 in man,and to mouse chromosome 10 in the region of the dystrophia muscularis (dy) locus |
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| Authors: | V J Buckle J L Guenet D Simon-Chazottes D R Love K E Davies |
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| Institution: | (1) Institute of Molecular Medicine, John Radcliffe Hospital, OX3 9DU Headington, Oxford, UK;(2) Institut Pasteur, 28, Rue du Dr. Roux, 15 Paris Cedex, France |
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| Abstract: | Summary We have localised a dystrophin-related autosomal gene called DMDL (Duchenne muscular dystrophy-like) to human chromosome 6q24 by in situ hybridisation. Using restriction fragment length polymorphism analysis in two mouse species, we have localised the homologous gene Dmdl in the mouse to chromosome 10 proximal to the Myb oncogene. A neuromuscular disease locus dystrophia muscularis (dy) has previously been assigned to this region of mouse chromosome 10. |
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