Structure and function of clostridial phospholipases C |
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Authors: | Jepson M Titball R |
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Institution: | Defence Evaluation and Research Agency, CBD, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK. |
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Abstract: | A range of clostridial species produce phospholipases C. The zinc metallo phospholipases C have related sequences but different properties. All of these enzymes may be arranged, like alpha-toxin as two-domain proteins. Differences in enzymatic, haemolytic and toxic properties may be explained by differences in amino acids at key positions. |
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