Three dimensional observation of the nerve fibers along the cerebral blood vessels |
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| Authors: | T Hakura K Nakakita H Imai K Nakai I Kamei Y Naka T Okuno N Komai T Hirai T Arai H Komi |
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| Institution: | (1) Department of Neurological Surgery, Wakayama Medical College, 7-1 Wakayama City, Japan;(2) Analytical Application Laboratory, Shimadzu Corporation, Kyoto City, Japan |
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| Abstract: | Summary Three dimensional observation of the nerve fibers along the cerebral blood vessels was investigated by scanning electron microscopy. Electron probe X-ray microanalysis was also performed in the cerebral blood vessels treated with peroxidase-antiperoxidase immunohistochemistry intensified by nickel ammonium sulfate.Nerve fibers (2–8  m in diameter) formed a plexus on the outer surface of the adventitia. After branching, the nerve fibers penetrated the blood vessel adventitia. Substance P-immunoreactive nerve fibers showed a meshwork pattern in the outer layer of the adventitia, and vasoactive intestinal polypeptide (VIP)-immunoreactive nerve fibers revealed a spiral running pattern in the inner layer of the adventitia. Taken together with previous studies, these findings suggest that substance P nerve fibers in the cerebral arteries may not be related to arterial dilatation or constriction, but VIP nerve fibers may be vasodilative. |
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