New chitosan derivatives with potential antimicrobial activity |
| |
Authors: | G. A. Naberezhnykh S. I. Bakholdina V. I. Gorbach T. F. Solov’eva |
| |
Affiliation: | (1) Department of Biophysics, Faculty of Science, Cairo University, Cairo, 12613, Egypt;(2) Department of Labeled Compounds, Hot Labs Center, Atomic Energy Authority, Cairo, Egypt;(3) Departement of Nuclear Engineering, Faculty of Engineering, King-Abdoualziz, Jeddah, Saudi Arabia;(4) Department of Chemistry, Faculty of Science, Cairo University, Cairo, 12613, Egypt; |
| |
Abstract: | A series of four water-soluble chitosan derivatives differing in molecular mass, hydrophobicity, and charge was synthesized and tested for the intensity of their effects on Gram-negative and Gram-positive bacteria. It was shown that the tested compounds allowed the penetration of ethidium bromide into the bacteria, which showed increased permeability of their cell walls under the effect of chitosans. The tolerance to various chitosan derivatives differed in Gram-negative and Gram-positive bacteria. The Gram-negative bacteria were the most responsive to high-molecular chitosan and the Gram-positive ones, to N-,O-carboxypropylchitosan, whereas high-molecular chitosan had little effect. Research on the correlation between the structure and activity of the studied compounds revealed that depolymerization of chitosan reduced, and introduction of hydrophobic substantives in chitosan molecule significantly enhanced its permeability effect on bacterial cell walls. The obtained results provide a basis for the construction of new chitosan derivatives with antimicrobial activities. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|