A minimal domain responsible for Munc13 activity |
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| Authors: | Basu Jayeeta Shen Nan Dulubova Irina Lu Jun Guan Rong Guryev Oleg Grishin Nick V Rosenmund Christian Rizo Josep |
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| Institution: | Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA. |
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| Abstract: | Munc13 proteins are essential in neurotransmitter release, controlling the priming of synaptic vesicles to a release-ready state. The sequences responsible for this priming activity are unknown. Here we identify a large alpha-helical domain of mammalian Munc13-1 that is autonomously folded and is sufficient to rescue the total arrest in neurotransmitter release observed in hippocampal neurons lacking Munc13s. |
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