敌鼠钠对大鼠抗生育作用的研究

采用不同剂量敌鼠钠分别对SD妊娠大鼠和雄性大鼠一次性灌胃给药 ,观察敌鼠钠对大鼠的抗生育作用。结果表明 ,( 1 ) 5 0 0、2 50和 1 2 5mg/kg体重的敌鼠钠使妊娠大鼠活胎率显著下降 (P <0 0 1 ) ;( 2 )敌鼠钠致死胎的半数有效剂量 (ED50 )为 ( 1 60 2± 0 67)mg/kg体重 ;( 3)形态学观察表明 ,敌鼠钠导致雄性大鼠睾丸曲细精管管壁萎缩、变形并明显变薄 ,致使精母细胞、精子细胞和精子损伤 ,生精细胞层和精子层厚度明显变薄。提示敌鼠钠对雌性及雄性大鼠均有一定的抗生育作用。

Research of Diphacine-Na on Anti-fertility of Rats

In this present study, the effects of anti-fertility of Diphacine-Na on the pregnancy rats and the males were investigated. The results are as follows: (1) Compared with control group, the ratio of live fetus of the high dose groups, such as 5.0, 2.5 and 1.25!mg/kg were markedly decreased(P<0.01)；(2) The half effective dose ( ED50) of Anti-pregnancy was measured to be (1.602±0.676)!mg/kg；(3) The morphological examinations indicated that Diphacine-Na caused testicular lesion in contrast with that of the control group. Spermatozoa, spermatid and spermatocytes in seminiferous tubules were mainly damaged. Meanwhile the wall of seminiferous tubules became atrophy, deformities and thin obviously. These results suggest that Diphacine-Na has anti-fertility effect on rats.