The effect of warfarin and vitamin K-1 on the carboxylation and glycosylation of prothrombin in vivo

The effect of warfarin and vitamin K-1 on the carboxylation and glycosylation of prothrombin in the rat in vivo was investigated. Neither warfarin nor vitamin K-1 has an effect on carboxylation. However, warfarin inhibited glycosylation 80–90% and this inhibition was readily reversed by the administration of vitamin K-1.