Effect of <Emphasis Type="Italic">Tridax procumbens</Emphasis> on liver antioxidant defense system during lipopolysaccharide-induced hepatitis in D-galactosamine sensitised rats |
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Authors: | Vilwanathan?Ravikumar Kanchi?Subramanian?Shivashangari Email author" target="_blank">Thiruvengadam?DevakiEmail author |
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Institution: | (1) Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India;(2) Department of Biochemistry, University of Madras, Guindy Campus, Chennai, 600 025, India |
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Abstract: | The present study was carried out to assess the effect of chloroform insoluble fraction of ethanolic extract of Tridax procumbens (TP) against D-Galactosamine/Lipopolysaccharide (D-GalN/LPS)-induced hepatitis in rats. Induction of rats with D-GalN/LPS (300 mg/kg body weight/30 g/kg body weight) led to a marked increase in lipid peroxidation as measured by thiobarbituric acid reactive substances (TBARS) in liver. Further there was a decline in the activities of enzymic antioxidants such as superoxide dismutase, catalase, glutathione peroxidase, glutathione s-transferase and the levels of non-enzymic antioxidants namely reduced glutathione, vitamin C and vitamin E. These biochemical alterations were normalised upon pretreatment with TP extract. Thus, the above results suggest that TP (300 mg/kg body weight orally for 10 days) is very effective in allievating the D-GalN/LPS-induced oxidative stress suggesting its antioxidant property. (Mol Cell Biochem 269: 131–136, 2005) |
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Keywords: | antioxidants D-Galactosamine hepatitis lipid peroxidation lipopolysaccharide Tridax procumbens |
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