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Effect of Tridax procumbens on liver antioxidant defense system during lipopolysaccharide-induced hepatitis in D-galactosamine sensitised rats
Authors:Vilwanathan?Ravikumar,Kanchi?Subramanian?Shivashangari,Thiruvengadam?Devaki  author-information"  >  author-information__contact u-icon-before"  >  mailto:devakit@yahoo.co.uk"   title="  devakit@yahoo.co.uk"   itemprop="  email"   data-track="  click"   data-track-action="  Email author"   data-track-label="  "  >Email author
Affiliation:(1) Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India;(2) Department of Biochemistry, University of Madras, Guindy Campus, Chennai, 600 025, India
Abstract:The present study was carried out to assess the effect of chloroform insoluble fraction of ethanolic extract of Tridax procumbens (TP) against D-Galactosamine/Lipopolysaccharide (D-GalN/LPS)-induced hepatitis in rats. Induction of rats with D-GalN/LPS (300 mg/kg body weight/30 mgrg/kg body weight) led to a marked increase in lipid peroxidation as measured by thiobarbituric acid reactive substances (TBARS) in liver. Further there was a decline in the activities of enzymic antioxidants such as superoxide dismutase, catalase, glutathione peroxidase, glutathione s-transferase and the levels of non-enzymic antioxidants namely reduced glutathione, vitamin C and vitamin E. These biochemical alterations were normalised upon pretreatment with TP extract. Thus, the above results suggest that TP (300 mg/kg body weight orally for 10 days) is very effective in allievating the D-GalN/LPS-induced oxidative stress suggesting its antioxidant property. (Mol Cell Biochem 269: 131–136, 2005)
Keywords:antioxidants  D-Galactosamine  hepatitis  lipid peroxidation  lipopolysaccharide  Tridax procumbens
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