The radioreceptor assay: a simple, sensitive and rapid analytical procedure |
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| Authors: | J W Ferkany |
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| Affiliation: | 1. Queensland Alliance for Environmental Health Sciences, The University of Queensland, QLD, Australia;2. Department of Chemistry and Physics, University of Almeria, Agrifood Campus of International Excellence (CeiA3) Almería, 04120, Spain;3. Murdoch Children''s Research Institute, Royal Children''s Hospital, University of Melbourne, VIC, Australia;4. Melbourne Dementia Research Centre, The University of Melbourne, Melbourne, VIC, Australia;5. Department of Clinical Pathology, The University of Melbourne, VIC, Australia;6. The Florey Institute of Neuroscience & Mental Health, Parkville, VIC, Australia;7. Children''s Health and Environment Program, The University of Queensland, QLD, Australia;1. Department of Mechanical Engineering, University of Maryland, College Park, MD 20742, USA;2. National Renewable Energy Laboratory (NREL), Golden, CO 80401, USA |
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| Abstract: | Radioreceptor assays (RRAs) are analogous in concept to radioimmuno assays. Characteristic to both methods is the saturable, specific, competitive and reversible ligand/receptor interaction. The RRA is simple, sensitive and reproducible and provides a degree of precision comparable to more sophisticated analytical techniques. Since RRAs require little specialized equipment, they can be used routinely by any laboratory engaged in biochemical research or, as an inexpensive exercise to teach the fundamentals of ligand binding and analytical pharmacology. |
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