Heterotrimeric G protein activation by G-protein-coupled receptors |
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Authors: | Oldham William M Hamm Heidi E |
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Institution: | Department of Pharmacology, Vanderbilt University School of Medicine, 442 Robinson Research Building, 2222 Pierce Avenue, Nashville, TN 37232-6600, USA. |
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Abstract: | Heterotrimeric G proteins have a crucial role as molecular switches in signal transduction pathways mediated by G-protein-coupled receptors. Extracellular stimuli activate these receptors, which then catalyse GTP-GDP exchange on the G protein alpha-subunit. The complex series of interactions and conformational changes that connect agonist binding to G protein activation raise various interesting questions about the structure, biomechanics, kinetics and specificity of signal transduction across the plasma membrane. |
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