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Consolidating the set of known human protein-protein interactions in preparation for large-scale mapping of the human interactome

Authors:	Arun?K?Ramani,Razvan?C?Bunescu,Raymond?J?Mooney author-information" > author-information__contact u-icon-before" > mailto:mooney@cs.utexas.edu" title=" mooney@cs.utexas.edu" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Edward?M?Marcotte author-information" > author-information__contact u-icon-before" > mailto:marcotte@icmb.utexas.edu" title=" marcotte@icmb.utexas.edu" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author

Affiliation:	(1) Center for Systems and Synthetic Biology and Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712, USA;(2) Department of Computer Sciences, University of Texas, Austin, TX 78712, USA;(3) Department of Chemistry and Biochemistry, University of Texas, Austin, TX 78712, USA

Abstract:	Background Extensive protein interaction maps are being constructed for yeast, worm, and fly to ask how the proteins organize into pathways and systems, but no such genome-wide interaction map yet exists for the set of human proteins. To prepare for studies in humans, we wished to establish tests for the accuracy of future interaction assays and to consolidate the known interactions among human proteins.

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