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Evaluation of the trypanocidal and leishmanicidal in vitro activity of the crude hydroalcoholic extract of Pfaffia glomerata (Amarathanceae) roots |
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| Authors: | AG Neto AA da Silva Filho JMLC Costa AHC Vinholis GHB Souza WR Cunha MLAE Silva S Albuquerque JK Bastos |
| Institution: | aMestrando do Curso de Pós-Graduação “Strictu Sensu” em Promoção de Saúde, Universidade de Franca, Franca, SP, Brazil bNúcleo de Pesquisa em Ciências Exatas e Tecnológicas, Universidade de Franca, Franca, SP, Brazil cCurso de Odontologia, Universidade de Franca, Franca, SP, Brazil dFaculdade de Ciências Farmacêuticas de Ribeirão Preto da Universidade de São Paulo, Brazil |
| Abstract: | Three different concentrations (1, 10 and 50 μg/ml) of lyophilized hydroalcoholic crude extract of Pfaffia glomerata roots were assayed in vitro against strains of Trypanosoma cruzi (Y) and Leishmania braziliensis. It was observed that P. glomerata hydroalcoholic extract was relatively active within the tested concentrations for L. (V.) braziliensis, but inactive against T. cruzi. Despite the fact that both protozoans belong to the Trypanosomatidae family, we suggest that the difference observed for activity should be related to the biological differences between the two parasite species. |
| Keywords: | Pfaffia glomerata Amaranthaceae Trypanosoma cruzi Chagas’ disease Leishmanicidal activity Leishmania braziliensis |
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