小儿肺热咳喘颗粒联合雾化吸入用乙酰半胱氨酸溶液对支气管肺炎患儿肺通气功能、炎症因子和免疫球蛋白的影响

摘要 目的：观察小儿肺热咳喘颗粒联合雾化吸入用乙酰半胱氨酸溶液对支气管肺炎患儿肺通气功能、炎症因子和免疫球蛋白的影响。方法：选择2019年9月-2023年1月期间合肥市第二人民医院收治的100例支气管肺炎患儿，采用双色球法将患儿分为对照组和研究组，各为50例。对照组患儿接受雾化吸入用乙酰半胱氨酸溶液，研究组患儿在对照组的基础上接受小儿肺热咳喘颗粒。对比两组临床症状、炎症因子水平白细胞介素-6（IL-6）、降钙素原（PCT）、C反应蛋白（CRP）]、免疫球蛋白免疫球蛋白（Ig）A、IgM、IgG]、肺通气功能指标吸气时间（TI）、呼气时间（TE）、吸呼比（TI/TE）、达峰时间比（TPF%TE）、达峰容积比（VPF%VE）]和不良反应发生率。结果：与对照组相比，研究组的肺部湿啰音消失时间、咳嗽消失时间、咳痰消失时间、退热时间更短（P<0.05）。研究组治疗10 d后CRP、IL-6、PCT低于对照组（P<0.05）。研究组治疗10 d后IgA、IgM、IgG高于对照组（P<0.05）。研究组治疗10 d后VT、TI、TE、TI/TE、TPF%TE、VPF%VE高于对照组（P<0.05）。两组不良反应发生率对比未见差异（P>0.05）。结论：小儿肺热咳喘颗粒联合雾化吸入用乙酰半胱氨酸溶液治疗支气管肺炎，可有效缩短临床症状缓解时间，改善肺通气功能，降低炎症因子水平，调节免疫球蛋白，且安全性较好。

Effects of Xiaoer Feire Kechuan Granules Combined with Acetylcysteine Solution for Aerosol Inhalation on Pulmonary Ventilation Function, Inflammatory Factor and Immunoglobulin in Children with Bronchial Pneumonia

ABSTRACT Objective: To observe the effects of xiaoer feire kechuan granules combined with acetylcysteine solution for aerosol inhalation on pulmonary ventilation function, inflammatory factor and immunoglobulin in children with bronchial pneumonia. Methods: 100 children with bronchial pneumonia who were admitted to theHefei Second People''s Hospital from September 2019 to January 2023 were selected, and children were divided into control group and study group by double chromosphere method, with 50 cases in each group. Children in control group were treated with acetylcysteine solution for aerosol inhalation, and children in study group were treated with xiaoer feire kechuan granules on the basis of control group. The clinical symptoms, inflammatory factor levels interleukin-6 (IL-6), procalcitonin (PCT), C-reactive protein (CRP)], immunoglobulin immunoglobulin (Ig) A, IgM, IgG], pulmonary ventilation function indexes inspiratory time (TI), expiratory time (TE), inspiratory-expiratory ratio (TI/TE), peak time ratio (TPF%TE), peak volume ratio (VPF%VE)] and incidence of adverse reactions were compared between two groups. Results: Compared with control group, the disappearance time of lung wet rales, disappearance time of cough, disappearance time of expectoration and disappearance time of fever in study group were shorter(P<0.05). CRP, IL-6 and PCT in study group were lower than those in control group 10 days after treatment (P<0.05). IgA, IgM and IgG in study group were higher than those in control group 10 days after treatment (P<0.05). TI, TE, TI/TE, TPF%TE and VPF%VE in study group were higher than those in control group 10 days after treatment (P<0.05). There was no difference in the incidence of adverse reactions between two groups(P>0.05). Conclusion: The combination of xiaoer feire kechuan granules and acetylcysteine solution for aerosol inhalation in the treatment of bronchial pneumonia could effectively shorten the remission time of clinical symptoms, improve pulmonary ventilation function, reduce the level of inflammatory factor, regulate immunoglobulin, and had good safety.