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Cilia-related diseases |
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| Authors: | Zhanhong Ren Xiaoxiao Mao Siqi Wang Xin Wang |
| Affiliation: | 1. Hubei Key Laboratory of Diabetes and Angiopathy, Medicine Research Institute, Xianning Medical College, Hubei University of Science and Technology, Xianning, P. R. China Contribution: Conceptualization (equal), Writing - review & editing (equal);2. Hubei Key Laboratory of Diabetes and Angiopathy, Medicine Research Institute, Xianning Medical College, Hubei University of Science and Technology, Xianning, P. R. China School of Basic Medical Sciences, Xianning Medical College, Hubei University of Science and Technology, Xianning, P. R. China Contribution: Writing - original draft (equal);3. Hubei Key Laboratory of Diabetes and Angiopathy, Medicine Research Institute, Xianning Medical College, Hubei University of Science and Technology, Xianning, P. R. China Contribution: Writing - review & editing (equal);4. School of Mathematics and Statistics, Hubei University of Science and Technology, Xianning, P. R. China |
| Abstract: | More and more attention is paid to diseases such as internal transfer and brain malformation which are caused by the abnormal morphogenesis of cilia. These cilia-related diseases are divided into two categories: ciliopathy resulting from defects of primary cilia and primary ciliary dyskinesia (PCD) caused by functional dysregulation of motile cilia. Cilia are widely distributed, and their related diseases can cover many human organs and tissues. Recent studies prove that primary cilia play a key role in maintaining homeostasis in the cardiovascular system. However, molecular mechanisms of cilia-related diseases remain elusive. Here, we reviewed recent research progresses on characteristics, molecular mechanisms and treatment methods of ciliopathy and PCD. Our review is beneficial to the further research on the pathogenesis and treatment strategies of cilia-related diseases. |
| Keywords: | cilia ciliopathy motile cilia primary cilia primary ciliary dyskinesia |