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Synthesis, characterization and cytotoxic effect of ring-substituted and ansa-bridged vanadocene complexes |
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| Authors: | Jan Honzí?ek Iva Klepalová Zdeňka Padělková Pavel Šiman |
| Institution: | a Department of General and Inorganic Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 532 10 Pardubice, Czech Republic b Department of Inorganic Chemistry, Faculty of Natural Science, Charles University in Prague, Hlavova 2030, 128 40 Praha 2, Czech Republic c Department of Medical Biochemistry, Faculty of Medicine in Hradec Králové, Charles University in Prague, Šimkova 870, 500 01 Hradec Králové, Czech Republic |
| Abstract: | The cytotoxic effect of vanadocene dichloride (Cp2VCl2, 1) and its ring-substituted, (η5-C5H4Me)2VCl2 (2), (η5-C5Me5)2VCl2 (3), (η5-C5H4R)2VCl2 (4: R = MeOCH2CH2-, 5: R = 2-MeOC6H4CH2-, 6: R = 4-MeOC6H4CH2-) and ansa-bridged analogs Me2C(η5-C5H4)2VCl2 (7) and Me4C2(η5-C5H4)2VCl2 (8) was investigated. Synthesis of two new methoxy-functionalized compounds (4 and 5) is described. They were characterized by spectroscopic methods and X-ray diffraction analysis. The cytotoxicity studies were performed with leukemic cells MOLT-4. |
| Keywords: | Bent metallocene Vanadocene dichloride Cytotoxicity Antitumor agent X-ray structure Leukemia |
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