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Structures, redox behavior, antibacterial activity and correlation with electronic structure of the complexes of nickel triad with 3-(2-(alkylthio)phenylazo)-2,4-pentanedione |
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| Authors: | Mrinal Kanti Paira Durbadal Ojha Edward RT Tiekink Chittaranjan Sinha |
| Institution: | a Inorganic Chemistry Section, Department of Chemistry, Jadavpur University, Kolkata 700032, India b Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India c Department of Chemistry, University of St. Andrews, St. Andrews, Fife KY16 9ST, UK d Department of Chemistry, University of Malaya, Kuala Lumpur 50603, Malaysia |
| Abstract: | 3-(2-(Alkylthio)phenylazo)-2,4-pentanedione (HL), an O, N, S donor ligand, is used for the synthesis of Ni(II), Pd(II) and Pt(II) complexes. The spectroscopic (IR, UV-Vis, and NMR) data determine the structure. The single crystal X-ray diffraction measurement of Ni(L)2] and Pt(L)Cl] has confirmed the structures. Coulometric oxidation of Ni(L)2] and EPR spectra thereof show formation of Ni(III) state. DFT computation has calculated the electronic configuration and has explained the spectral and redox properties of the complexes. The compounds are screened for their in vitro anti-bacterial activity using Gram-positive and Gram-negative bacteria (Bacillus subtilis UC564, Escherichia coli TG1, Staphylococcus aureus Bang25, Pseudomonas aeruginosa C/1/7, Salmonella typhi NCTC62, Salmonella paratyphi NCTC A2, Shigella dysenteriae 8NCTC599/52, Streptococcus faecalis S2, Vibrio cholerae DN7 and Mricococcus luteusAGD1). The minimum inhibitory concentration is determined for the compounds. The effect of the structure of the investigated compounds on the antibacterial activity is discussed. |
| Keywords: | 3-(2-(Alkylthio)phenylazo)-2 4-pentanedione Group 10 metals Structure Redox Antibacterial activity DFT computation |
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