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Malonato complexes of oxidovanadium(IV): Synthesis, structural characterization and exploration of their insulin mimetic properties |
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| Authors: | Manas Sutradhar Tannistha Roy Barman Manoj Kar Michael GB Drew |
| Institution: | a Department of Chemistry, University of Calcutta, University College of Science, 92, Acharya Prafulla Chandra Road, Kolkata 700 009, India b Institute of Inorganic and Analytical Chemistry, Johannes Gutenberg University of Mainz, Duesbergweg 10-14, D-55128 Mainz, Germany c Department of Biochemistry, N.R.S. Medical College and Hospital, Kolkata 700 014, India d School of Chemistry, The University of Reading, P.O. Box 224, Whiteknights, Reading RG6 6AD, UK |
| Abstract: | Several bis-malonatooxidovanadium(IV) complexes of the general type M2(H2O)n]VO(mal)2(H2O)] (where M = Li(1), Na(2), K(3), Cs(4) and NH4(5); n = 3.5, 1, 3, 1 and 1, respectively) were isolated in good yield and high purity. These complexes were fully characterized by various physicochemical techniques (elemental analysis, UV-Vis, IR, EPR, CV, etc.) complexes 1, 2 and 3 were structurally characterized by single crystal X-ray diffraction technique. In vivo antidiabetic properties of bis-malonato complexes 1, 2, 3 and 5 have been studied using Streptozotocin induced diabetic rats. Significant lowering of blood sugar level has been noticed. At the same time these complexes were found to regulate secondary pathophysiological complications like liver damage and lowering of the total antioxidant status (TAS) in diabetic rats. Results of these study are expected to a expand the possibility of designing new oxidovanadium(IV) complexes of O,O chelating ligands with significant antidiabetic properties. |
| Keywords: | Oxidovanadium(IV) complexes O O chelating ligand Antidiabetic activity X-ray crystallography |
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