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Synthesis, characterization and in vitro antitumor activity of three organotin(IV) complexes with carbazole ligand |
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| Authors: | Banfeng Ruan Hongping Zhou Chenhao Zhu Hailiang Zhu |
| Affiliation: | a Department of Chemistry, Key Laboratory of Inorganic Materials Chemistry of Anhui Province, Anhui University, Hefei 230039, PR China b State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China c State key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, PR China d Anhui Research Institute of Chemical Industry, Hefei 230039, PR China |
| Abstract: | Three novel organotin(IV) complexes with 2-(9H-carbazol-9-yl) acetic acid (HL), of the formulae {[nBu2SnOL]2O}2 (1), [nBuSn(O)OL]6 (2) and [nBu3SnOL]6 (3) were prepared. All compounds were characterized by X-ray crystallography, confirming that complex (1) is tetranuclear one with ladder framework, complex (2) is a hexanuclear organotin(IV) complex with drum structure and complex (3) is a macrocycle with 24-membered stannoxane ring. Furthermore, all complexes were tested in vitro for their cytotoxic activity, using human hepatocellular carcinoma cell line (BEL-7402) and human hepatocellular liver carcinoma cell line (HepG2). Complex (1) displayed the best cytotoxicity and can be pointed out as a promising substrate to be subject of further investigations. |
| Keywords: | Carbazole Organotin(IV) carboxylate Single crystal diffraction Antitumor activity |
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