MAB21L2, a vertebrate member of the Male-abnormal 21 family,modulates BMP signaling and interacts with SMAD1 |
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| Authors: | Danila?Baldessari Aurora?Badaloni Renato?Longhi Vincenzo?Zappavigna Email author" target="_blank">G?Giacomo?ConsalezEmail author |
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| Institution: | (1) Dept. Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy;(2) Stem Cell Research Institute, San Raffaele Scientific Institute, 20132 Milan, Italy;(3) Dept. Molecular Biology and Functional Genomics, San Raffaele Scientific Institute, 20132 Milan, Italy;(4) National Research Center, Institute of Chemistry of Molecular Recognition, 20131 Milan, Italy |
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| Abstract: | Background Through in vivo loss-of-function studies, vertebrate members of the Male abnormal 21 (mab-21) gene family have been implicated in gastrulation,
neural tube formation and eye morphogenesis. Despite mounting evidence of their considerable importance in development, the
biochemical properties and nature of MAB-21 proteins have remained strikingly elusive. In addition, genetic studies conducted
in C. elegans have established that in double mutants mab-21 is epistatic to genes encoding various members of a Transforming Growth Factor beta (TGF-beta) signaling pathway involved
in the formation of male-specific sensory organs. |
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