Chemoenzymatic syntheses of homo- and heterodimers of AZT and d4T, and evaluation of their anti-HIV activity |
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| Authors: | Taourirte M Mohamed L Ait Rochdi A Vasseur J J Fernández S Ferrero M Gotor V Pannecouque C De Clercq E Lazrek H B |
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| Institution: | Faculty of Sciences and Techniques Gueliz, Marrakesh, Morocco. |
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| Abstract: | Homo- and heterodimers of AZT and d4T, possessing carbonate and carbamate linkers, have been synthesized with the aim to enhance the antiviral activity of their components. Homo- and heterodimer carbamates showed weak anti-HIV activity. On the other hand, dinucleoside carbonates showed marked antiviral activity. |
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