Base sequence of a non-self-complementary messenger RNA of human heart cytochrome |
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Authors: | R Figueroa A Soto G González M Pieber C Romero J C Tohá |
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Affiliation: | Departamento de Fisica-Biofísica, Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile, Casilla 5487, Santiago, Chile S.A. |
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Abstract: | The messenger RNAs of 72 natural proteins built using only the first two bases of their animo acid codons show that antiparallel auto-complementarities of four or more successive bases are avoided. Supported by this fact, the third base of each codon of the mRNA of human heart cytochrome c was selected, choosing every time (with a computer) that base which induced the lowest number of antiparallel anti-complementarities of four or more successive bases with all the nucleotides of the rest of messenger. The cytochrome messenger found has no antiparallel auto-complementarity of five or more successive bases and only 51 of four. Thus at 37 °C, a monotenic structure of messenger would be preferred. |
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