Comparison of the photochemical and enzymic generation of excited states of oxygen on the induction of benzo(alpha)pyrene mono-oxygenase in liver cell cultures. |
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| Authors: | A J Paine |
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| Affiliation: | The British Industrial Biological Research Association, Woodmansterne Road, Carshalton, Surrey SM5 4DS United Kingdom |
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| Abstract: | The photochemical generation of excited states of oxygen such as the superoxide ion(O-2) and singlet oxygen (1o2) by the mild illumination of culture medium containing riboflavin induces benzo(alpha)pyrene mono-oxygenase in 3 different cell lines derived from rat liver. Similar rates of O-2 generation can be produced by the action of xanthine oxidase on xanthine yet this system does not induce the mono-oxygenase. This result confirms that the mono-oxygenase induction is not mediated by O-2 is not mediated by O-2 and that 1O2 is the most likely candidate for stimulating the mono-oxygenase activity. |
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| Keywords: | DMNA dimethylnitrosamine ER endoplasmic reticulum G-6-P glucose-6-phosphatase NPY N-nitrosopyrrolidine PAS periodic acid-Schiff RLW relative liver weight SER smooth endoplasmic reticulum |
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